Combined biosensors
https://doi.org/10.25206/1813-8225-2026-198-122-129
EDN: RVMSUO
Abstract
The article presents the development of the design of sensitive elements of reusable sensors for simultaneous registration of parameters of vital systems of the human body and experimental verification of the technical features of prototype samples.
The author uses methods of designing and manufacturing multilayer printed circuit boards, 3D modeling of the sensors design and their interface with existing solutions. Computational methods are also applied to the dependence model of sensor features on changes in temperature and concentration of the measured substances. Moreover, an experimental approbation of an experimental batch of sensors is carried out.
The research suggests technical solutions for the design of sensors for simultaneous registration of several parameters of the human body in long-term monitoring of vital systems of the human body such as reusable combined electrodes "ECG temperature" and "ECG metabolism". Technological capabilities of the production of standard printed circuit boards are used for the manufacture of sensors, due to which the high manufacturability and low cost of sensors are achieved.
Sensors can be used both for short-term monitoring of a patients’ condition during functional and pharmacological tests and for long-term recording of parameters as part of wearable multi-channel human body monitoring systems.
About the Author
D. N. KlypinRussian Federation
Klypin Dmitrii Nikolayevich, Senior Researcher, Research Laboratory “Microprocessor Devices”, Research Institute of Radioelectronics and Instrument Engineering
Mira Ave., 11, Omsk, 644050
AuthorID (RSCI): 681588
AuthorID (SCOPUS): 37111005000
ResearcherID: E-7467-2014
References
1. Tychkov A. Yu., Butrov N. A., Alimuradov A. K., Nazarychev A. P. Multichannel system for monitoring the main indicators of human health. University Proceedings. Volga Region. Engineering Sciences. 2021;2:3–14. https://doi.org/10.21685/2072-3059-2021-2-1. (In Russ.).
2. Yuldashev Z. M. A Remote System for Monitoring the State of Health of People with Chronic Diseases and Predicting Periods of Exacerbation. Biomedical Engineering. 2023;5(56):294–297. https://doi.org/10.1007/s10527-023-10222-w. EDN: AAYZRR.
3. Yang H. Wearable flexible temperature sensors and their applications. Highlights in Science, Engineering and Technology. 2024;102:124–128.
4. Momynaliev K. T., Prokopiev M. V., Ivanov I. V. Overview of modern sensors for continuous glucose monitoring. Diabetes Mellitus. 2023;26(6):575–584. https://doi.org/10.14341/DM13043. EDN: DFUNWV. (In Russ.).
5. Vokhmyanina D. V., Karyakina E. E., Andreev E. A., Karyakin A. A. Thin-film prussian blue based multibiosensor for glucose and lactate simultaneous determination. Vestnik MSU. Chemistry Series. 2018;59(5):337–344. EDN: XPURNZ. (In Russ.).
6. Bakker J., Nijsten M. W., Jansen T. C. Clinical use of lactate monitoring in critically ill patients. Annals of Intensive Care. 2013;3(1):12. https://doi.org/10.1186/2110-5820-3-12.
7. Luo T. T., Sun Zh., Li C. [et al.]. Monitor for lactate in perspiration. The Journal of Physiological Sciences. 2021;71:26. https://doi.org/10.1186/s12576-021-00811-3.
8. Bandodkar A. J., Wang J. Non-invasive wearable electrochemical sensors: A review. Trends in Biotechnology. 2014;32(7):363–371. https://doi.org/10.1016/j.tibtech.2014.04.005.
9. Legner C., Kalwa U., Patel V. [et al.]. Sweat sensing in the smart wearables era: Towards integrative, multifunctional and body-compliant perspiration analysis. Sensors and Actuators A: Physical. 2019;296:200–221. 296. https://doi.org/10.1016/j.sna.2019.07.020.
10. Bariya M., Nyein H. Y. Y., Javey A. Wearable sweat sensors. Nature Electronics. 2018;1(3):160–171. https://doi.org/10.1038/s41928-018-0043-y.
11. Komkova M. A., Eliseev A. A., Poyarkov A. A. [et al.]. Simultaneous monitoring of sweat lactate content and sweat secretion rate by wearable remote biosensors. Biosensors and Bioelectronics. 2022;202:113970. https://doi.org/10.1016/j.bios.2022.113970.
12. Yang G., Hong J., Park S-B. Wearable device for continuous sweat lactate monitoring in sports: A narrative review. Frontiers in Physiology. 2024;15:1376801. https://doi.org/10.3389/fphys.2024.1376801.
13. Shitanda I., Ozone Yu., Morishita Yu. [et al.]. Airbubble-insensitive microfluidic lactate biosensor for continuous monitoring of lactate in sweat. ACS Sensors. 2023;8(6):2368–2374. https://doi.org/10.1021/acssensors.3c00490.
14. Hart J. P., Crew A., Crouch E. [et al.]. Some recent designs and developments of screen-printed carbon electrochemical sensors/biosensors for biomedical, environmental, and Industrial analyses. Analytical Letters. 2004;37:789–830. https://doi.org/10.1081/AL-120030682.
15. Gryaznova M. I., Lugvishchuk D. S., Gryaznov K. O. [et al.]. Screen-printing of electrical sensor for glucose determination with exfoliated graphite-based paste. Journal of Advanced Materials and Technologies. 2023;8(2):111–119. https://doi.org/10.17277/jamt.2023.02.pp.111-119.
Review
For citations:
Klypin DN. Combined biosensors. Omsk Scientific Bulletin. 2026;(2):122-129. (In Russ.) https://doi.org/10.25206/1813-8225-2026-198-122-129. EDN: RVMSUO
JATS XML





















